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However, it is crucial to evaluate the long-term safety of these nutrients, as extensive research indicates that nutrient supplementation can pose risks, including gastrointestinal distress, an increased incidence of bleeding, and a heightened prevalence of cancer and certain diseases, particularly in immunocompromised individuals and smokers

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Both studies concluded that vitamin E showed better effects on SBP reduction in the short term (up to 8 weeks) with a minimum dose of 80 mg/day, while in the duration of 6 months, the most significant BP reduction was noted with doses ranging from 18.75 to 40.53 mg/day